Comparative effectiveness of levothyroxine, desiccated thyroid extract, and levothyroxine+Liothyronine in hypothyroidism

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Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: a randomized, double-blind, crossover study.

CONTEXT Patients previously treated with desiccated thyroid extract (DTE), when being switched to levothyroxine (L-T₄), occasionally did not feel as well despite adequate dosing based on serum TSH levels. OBJECTIVE Our objective was to investigate the effectiveness of DTE compared with L-T₄ in hypothyroid patients. DESIGN AND SETTING We conducted a randomized, double-blind, crossover study ...

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Stability, Effectiveness, and Safety of Desiccated Thyroid vs Levothyroxine: A Rebuttal to the British Thyroid Association

In 2007, an Executive Committee (the Committee) of the British Thyroid Association (BTA) published a document in which it concluded that levothyroxine is safer, more stable, and more effective than Armour Thyroid. By extension, the conclusion also applies to other desiccated thyroid products, such as Erfa 4 3 Thyroid. Enough evidence is available, however, to conclude that T /T therapies with e...

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Synthetic or a Natural Thyroid Replacement: Should the Choice be Left to the Patient?

Data from National Health and Nutrition Examination Survey (NHANES 1999-2002) reveals 3.7% prevalence of hypothyroidism in the general population [1]. 10.3 million People or 4.6% of those surveyed reported use of thyroid hormones (levothyroxine, liothyronine, or desiccated thyroid) [1]. Desiccated Thyroid Extract (DTE) of animal origin has been used to treat hypothyroidism since 1892 [2,3]. Sev...

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Can Levothyroxine Be Taken as Evening Dose? Comparative Evaluation of Morning versus Evening Dose of Levothyroxine in Treatment of Hypothyroidism

152 drug naïve primary hypothyroid patients were divided into morning (Group 1) and evening (Group 2) dosing group and evaluated for change in biochemical profile, physical functioning and Quality of Life during the course of 12 weeks of study. At the end of 12 weeks 70 (90.90%) subjects in Group 1 and 72 (96%) in Group 2 achieved euthyroidism. On evaluation clinical symptoms and total clinical...

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ژورنال

عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism

سال: 2021

ISSN: 0021-972X,1945-7197

DOI: 10.1210/clinem/dgab478